The UK NSC recommendation on Down's syndrome screening in pregnancy
||Systematic population screening programme recommended
|Last review completed
|Next review due in
Evidence to support continuation or cessation of existing screening programmes should be reviewed regularly. The process for this is currently being revised, which is why this topic does not currently have a review date. The new process will be published in due course. Each programme has an active portfolio of research, evidence and audit to support continual improvement. Find out more about down's syndrome screening, as part of the fetal anomaly screening programme in England
Screening should be offered to all pregnant women.
The only substantial change made during the 2011 review was that the cut off threshold for all strategies at all stages of pregnancy has been agreed to be set at 1 in 150 at term and this must be implemented from the 1 October 2011.
Find general information about population health screening.
More about Down's syndrome
Down's syndrome (or 'Down syndrome'), a chromosomal disorder, occurs when, instead of the normal complement of two copies of chromosome 21, there is a whole, or sometimes part of an, additional chromosome 21.
Chromosome abnormalities give rise to specific physical features seen in Down's syndrome. The range of cognitive disabilities as well as other attributes is enormously wide in Down's syndrome. The majority are in the mild range of cognitive ability. Associated defects may include ear and/or eye defects, an increased propensity for infections and heart defects.
» Read more about Down's syndrome on the Contact a Family website
Screening in the UK
Compare how screening is offered across the UK.
• Down Syndrome Research Foundation UK
• Down's Syndrome Association
• Down's syndrome Medical Interest Group
• Royal College of General Practitioners
• Royal College of Obstetricians and Gynaecologists
• Society and College of Radiographers
The stakeholder groups will be involved when the recommendation is next reviewed.
If you think your organisation should be added, please
More about the recommendation review process, including the role of stakeholders,
can be found in the guide to Engaging with the UK NSC's recommendation review process.
Second trimester quadruple testing for T21 in twins (PDF document, 85KB, 16/07/14)
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